Electric Literature of 20850-43-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
[[00244]] To a solution of [4- (8-AZA-BICYCLO] [3.2. [1] OCT-3-] ylamino)-6-chloro-1-(2, 2, [2-TRIFLUORO-ETHYL)-LH-QUINAZOLIN-2-] one (149 mg, 0.320 mmol) in DMF (10 mL) was added triethylamine (0.3 mL) and 5-Chloromethyl-benzo [1, 3] dioxole [(0.] 061 mL, 0.480 mmol). The solution was heated to 50 C and stirred for 6 hrs. The reaction was partitioned between ethyl acetate and water and the organic phase was washed an additional 2 x with water and brine, dried over [NA2SO4,] filtered, and concentrated. The crude residue was purified by flash chromatography (gradient elution: [0-20%] MeOH/dichloromethane) to provide 99 mg white solid [(60%). 1H] NMR (300 MHz, CDCl3) 8 ppm 2.10 (m, 4 H), 2.32 (m, 2 H), 3.56 (m, 3 H), 3.77 (s, 2 H), 4.87 (m, 2 H), 5.96 (s, 2 H), 6.77 (d, J = 8.0 Hz, [1] H), 6.83 (m, [1] H), 6.95 (d, J = 8.1 Hz, [1] H), 7.17 (m, 2 H), 7.56 (dd, J = 2.3, 8.9 Hz, [1] H), 7.91 (s, [1] H); MS (ESI [+Q1MS)] m/z 522 [[M+2H] +]
The synthetic route of 5-(Chloromethyl)benzo[d][1,3]dioxole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2003/106452; (2003); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics