Adding a certain compound to certain chemical reactions, such as: 1996-30-1, name is 3-Bromo-4-fluorochlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1996-30-1, SDS of cas: 1996-30-1
A solution of iso-propylmagnesium chloride in tetrahydrofuran (2M, 106. 6ml) was added dropwise over 15 minutes to a stirred solutionof 2-bromo-4-chloro-1-fluorobenzene (42. 5g) in anhydrous tetrahydrofuran(250ml) at0 C under nitrogen. After a further 15 minutes, a solution ofl-oxa-6-azaspiro [2.5] octane-6-carboxylic acid,1, 1-dimethylethyl ester (43.2g) in anhydrous tetrahydrofuran(50ml) was added followed by copper (I) bromide dimethyl sulphide complex (0.4g). The mixture was stirred at40 C for 18 hours, cooled to20 C, diluted with water(300ml) and extracted with withtert.-butyl methyl ether (2 x300ml). Organic extracts were dried over anhydrous magnesium sulphate, filtered and evaporated under reduced pressure. The residual oil was dissolved in 1,2-dimethoxypropane(200ml). Potassium tert-butoxide (22.8g) was added and the mixture stirred at40 C for 16 hours then at50 C for 24 hours. Further potassium tert.- butoxide (5.7g) was added and stirring continued at50 C for 2 hours then at55 C for 4 hours. Water (500ml) was added and the mixture extracted with tert.-butyl methyl ether (2 x300ml). Organic extracts were dried over anhydrous magnesium sulphate, filtered and evaporated under reduced pressure to give the sub-title compound (47.45g, 67 %) as an oil. ‘H-NMR (400 MHz,CDC13) :8 1.47 (9h, s), 1.67 (2H, td), 1.85-1. 93 (2H, m), 2.94 (2H, s), 3.39 (2H, td), 3.65-3. 80 (2H,m), 6.67(1H, d), 7.06(1H, d), 7.10(1H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-4-fluorochlorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB?; WO2005/49620; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics