Electric Literature of 1871-57-4, These common heterocyclic compound, 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1-3; 1.7 g of methallyl dichloride and 8.9 g of the compound of Formula 11 were put into a reactor, and then 20 mL of tetrahydrofuran was added thereto. To the mixture was added dropwise 0.8 g of sodium hydride. The reactor was kept at 65 0C for 24 hr. 2 mL of water was added dropwise to the reactor. The reaction mixture was evaporated under vacuum to remove the tetrahydrofuran. The concentrate was extracted with 100 mL of diethyl ether and 100 mL of water. The organic layer was subjected to column chromatography using ethyl acetate/methanol (100/0-80/20), giving the compound of Formula 10 in a yield of 28%. 1H NMR (250 MHz, CDCl3): delta 5.18 (s, 2H; CH2), 4.02 (s, 8H; CH2(CH2O)2), 3.62-3.41 (m, 64H; OCH2), 3.37 (s,12H; OCH3), 2.22-2.04 (m, 4H; CH(OCH2)2)
The synthetic route of 1871-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY; JANG, Woo-Dong; CHOI, Kwang-Mo; WO2010/93128; (2010); A2;,
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