Reference of 70558-11-1, These common heterocyclic compound, 70558-11-1, name is 6-Chloro-3,4-dihydro-2H-benzo[b][1,4]oxazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 4 Production of (6-chloro-2,3-dihydrobenzo[1,4]oxazin-4-yl)-(3,5-dichloro-4-hydroxyphenyl)-methanone 6-Chloro-3,4-dihydro-2H-benzo[1,4]oxazine (168.4 mg) and 3,5-dichloro-4-hydroxybenzoyl chloride (242.7 mg) obtained in Step 1 of Example 3 were dissolved in ethyl acetate (3 mL), and the mixture was heated under reflux overnight. The solvent was evaporated, and the obtained solid was crystallized from methanol to give the title compound (318.4 mg) as white crystals.
Statistics shows that 6-Chloro-3,4-dihydro-2H-benzo[b][1,4]oxazine is playing an increasingly important role. we look forward to future research findings about 70558-11-1.
Reference:
Patent; Japan Tobacco Inc.; US2007/10670; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics