Electric Literature of 106-39-8,Some common heterocyclic compound, 106-39-8, name is 1-Bromo-4-chlorobenzene, molecular formula is C6H4BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
At room temperature, to a suitable solvent(a mixture of 1-Sulfobutyl-3-methylimidazolium trifluoromethansulfonate and 1,4-dioxane of volume ration 1:8),add add 100 mmol compound of the above formula (1), 180 mmol compound of the above formula (II), 7 mmol of a catalyst (2mmol of Pd (TFA) 2 and 5 mmol of CuBr), 10mmol of the bipyridine organic ligand of formula L3 and 20 mmol of trifluoroacetic acid, and then the temperature was raised to 80 C and the reaction was stirred at this temperature for 4 hours. After the reaction, The resulting reaction system is cooled to room temperature and filtered filtrate is saturated with sodium bicarbonate aqueous solution till no bubble remain. The acetone was extracted and the organic phase was separated and dried over anhydrous magnesium sulfate and distilled under pressure, the resulting residue was purified by flash column chromatography (elution solvent mixture of petroleum ether and ethyl acetate in a volume ratio of 15: 1) to give a compound of formula (III) ,yield of 96.5%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-chlorobenzene, its application will become more common.
Reference:
Patent; Jiang Yulan; Li Meiling; Han Deyu; Zheng Xuemei; (10 pag.)CN105152826; (2017); B;,
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