Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Chloro-2-chloromethyl-1-propene
Compound 1 (100 g, 0.8 mol)With 18-crown-6 ether (5 g)And pinacol (8 g)Dissolved in bromoform (400 g)An aqueous solution of sodium hydroxide (30% by mass, 1.0 L) was added dropwise at 10 C to 25 C,The reaction was then stirred at room temperature for 24 hours.TLC (petroleum ether / ethyl acetate = 10/1, volume ratio, the same below) shows the end of the reaction. The reaction system was concentrated and purified by column chromatography (petroleum ether / ethyl acetate = 5/1 to 1/1) to give compound 2 (168 g) in a yield of 70.7%
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shanghai Syn-The-All medical research and development Co . ltd; Shanghai Syn-The-All Pharmaceutical Co. Ltd.; CHANGZHOU HEQUAN PHARMACEUTICAL CO LTD; Wan, xiaojun; Bi, zengliang; Wang, HaiHui; Shen, wanjun; Peng, Yannan; Cheng, Yuan; Shao, WenQing; Chen, YuYan; Yuan, Xiaobin; Yu, LingBo; Li, Lei; Ha, Weijie; Chai, YanPing; Zhou, LeLe; Wu, Xuan; Zhu, Xiwen; Ma, Kunyan; Chen, Yuanli; He, Zhenmin; Ma, RuJian; Chen, Minzhang; Fu, XiaoYong; Wang, Wengui; (5 pag.)CN105294442; (2016); A;,
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