Month: November 2020

A common compound: 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 1996-29-8

In a 200 mL three-necked flask, the obtained white solid and 4.2 g (20 mmol) of 1-bromo-4-chloro-2-fluorobenzene, 6.1 g (19 mmol) of cesium carbonate were placed. To this mixture, 30 mL of N-methyl-2-pyrrolidone was added and the mixture was degassed by stirring while reducing the pressure. After degassing, the mixture was stirred at 120 C. for 7 hours under a nitrogen stream. After stirring, water was added to this mixture, and after ultrasonic irradiation, filtration was carried out to obtain a solid. The obtained solid was washed with water and ethanol. This solid was purified by silica gel column chromatography (developing solvent: toluene). The obtained solid was recrystallized from toluene / ethyl acetate to obtain 1.9 g of a white solid in a yield of 42%. The synthesis scheme of Step 2 is shown below.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1996-29-8, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Semiconductor Energy Laboratory Ltd.; Takeda, Kyoko; Ozaka, Harue; Seo, Tetsushi; Suzuki Tsune Toku; Hashimoto Naoaki; Takida Yuu Kai; (218 pag.)JP6339749; (2018); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

6940-78-9, name is 1-Bromo-4-chlorobutane, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 6940-78-9

Example Al l; a. Preparation of intermediate 75; A solution of l-bromo-4-chlorobutane (22.25 ml, 0.19 mol) in diethyl ether (100 ml) was added dropwise (under N2 atmosphere) to a suspension of activated Mg turnings (4.67 g, 0.19 mol) in diethyl ether (100 ml). Some crystals of iodine were also added. The temperature in the flask increased, and the orange colour turned to white. Once the addition of l-bromo-4-chlorobutane was completed, the reaction was cooled in an ice- bath and 2-naphthalenecarboxaldehyde (20.00 g, 0.13 mol) was added dropwise as a solution in THF (200 ml, dry). The reaction mixture was stirred in the ice-bath for 4 hours. Then the mixture was quenched with NH4Cl 1 N. Both phases were separated. The organic layer was washed with brine, dried (MgSO4), filtered and the solvent was evaporated. The residue was purified by flash chromatography (eluent: n- hexane/EtOAc 20:1). The desired fractions were collected and the solvent was evaporated, yielding intermediate 75.

Statistics shows that 6940-78-9 is playing an increasingly important role. we look forward to future research findings about 1-Bromo-4-chlorobutane.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/68266; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

6940-78-9, Adding some certain compound to certain chemical reactions, such as: 6940-78-9, name is 1-Bromo-4-chlorobutane, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-78-9.

Step 1 Synthesis of 1-(4-Chlorobutyl)-1,5,6,7-tetrahydroindol-4-one To a solution of 1,5,6,7-tetrahydroindol-4-one (10.0 g, 74.0 mmol) in acetone (300 mL) was added powdered sodium hydroxide (3.26 g, 81.4 mmol) and the mixture stirred at ambient temperature for 0.25 h. 1-Bromo-4-chlorobutane (9.38 mL, 81.4 mmol) was then added and the resulting mixture stirred at ambient temperature for 7 h after which time TLC (ethyl acetate:dichloromethane 1:1) showed complete reaction. The reaction was gravity filtered to remove salts, and the filtrate concentrated to dryness under vacuum. The resulting residue was dissolved in dichloromethane (200 mL) and gravity filtered again to remove more salts. The filtrate was then washed with water, dried with sodium sulfate, filtered and the solvent removed under vacuum to yield an oil. Flash chromatography using 6 in. of silica gel in a 5.5 cm column eluding with 1:1 followed by 2:1 ethyl acetate:hexane on half of the residue yielded 9.0 g of an oil which contained ~6.0 g of pure product (72%) and ~3.0 g of acetone aldol condensation product (4-hydroxy-4-methyl-2-pentanone). The oil was taken to the next step without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6940-78-9.

Reference:
Patent; Spectrum Pharmaceuticals, Inc.; US6770638; (2004); B2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A common heterocyclic compound, 2770-11-8, name is 2-(4-Chlorophenoxy)aniline, molecular formula is C12H10ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2770-11-8.

Preparation of l-(4-(2-(4-chIorophenoxy)phenylamino)azepan-l-yI)ethanoneSTX1762 C20H23ClN2O2, MW: 358.86To a solution of 2-(4-chlorophenoxy)phenylamine (113 mg, 0.51 mmol), 1-acetylazepan-4-one (159 mg, 1.02 mmol) and acetic acid (153 mg, 2.55 mmol) in DCE (4 ml), was added sodium triacetoxyborohydride (270 mg, 1.28 mmol). The reaction mixture was allowed to stir at room temperature for 10 days. On return, the reaction was quenched with saturated aqueous sodium sodium bicarbonateonate (15 ml) and extracted with ethyl acetate (2 x 15 ml). The combined organics were dried (MgSO4), filtered and concentrated in vacuo. Purification by flash chromatography then proceeded (eluent; 9:1 hexane:ethyl acetate to ethyl acetate) to afford the title compound as a pale yellow oil (67.1 mg, 37%).1H NMR (270 MHz, CDCl3): delta 1.49-2.27 (9H, m, 3 x CH2, CH3), 3.30- 3.72 (5H, m, 5 x CH), 4.10 (IH, br s, NH), 6.59-6.67 (2H, m, Ar-H), 6.78-6.89 (3H, m, Ar-H), 7.00-7.08 (IH, m, Ar-H), 7.21-7.24 ppm (2H, m, Ar-H). 13C NMR (67.93 MHz, CDC13): delta 21.9, 24.2, 25.3, 32.8, 33.0, 34.2, 35.2, 42.0, 45.0, 45.1, 48.3, 51.0, 52.0, 112.2, 118.6, 118.7, 125.4, 129.7, 129.8, 139.0, 142.8, 156.1, 156.2, 170.5 ppm. LCMS: EPO M+U: 359.45 HPLC: 95.92% (2.677 min, isocratic 90% acetonitrile, 10% water at 1 ml/min).

The synthetic route of 2-(4-Chlorophenoxy)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; STERIX LIMITED; WO2007/3934; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., 6579-54-0

b 2,6-dichlorobenzenesulfonamide A solution of 2,6-dichlorobenzenesulfonyl chloride (10.50 g, 42.77 mmol) in 100 mL of pyridine was added into 100 mL of pyridine dropwise while anhydrous ammonia gas was passing through the solution simultaneously for 4 hours at 0 C. The mixture was acidified to pH>1 with 6N aq. HCl, then extracted with ethyl acetate. The combined organic layer was then dried (Na2SO4) and concentrated to give the desired product (8.69 g, 90%). EI-MS (m/z) 225.0, 227.1 (M-).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Widdowson, Katherine Louisa; Jin, Qi; US2003/65170; (2003); A1;; ; Patent; Widdowson, Katherine Louisa; Jin, Qi; US2003/65188; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

56961-77-4, A common compound: 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

After dissolving 10 g (44 mmol) of 1-bromo-2,3-dichlorobenzene [1-bromo-2,3-dichlorobenzene] in 100 mL of toluene, diphenylamine (2.1eq, 92mmol), sodium t-butok Side [sodium t-butoxide] (2.7eq, 120mmol), BTP (Bis (tri-tert-butylphosphine) palladium (0)) (10mol%) was added and stirred under reflux for 3 hours to prepare intermediate 2 (2-chloro-N1, N1, N3, N3-tetraphenylbenzene-1,3-diamine) was synthesized. The obtained intermediate 2 was purified by column chromatography.Intermediate 2: m / z = 446.15 (C30H23ClN2)Yield = 15g (75.8%), Purity = 99.5%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2,3-dichlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LG Chem, Ltd.; Lee Gi-gon; Seo Sang-deok; Keum Su-jeong; Kim Myeong-gon; Kim Gyeong-hui; Lee Dong-hun; Park Tae-yun; Kim Dong-heon; Lee U-cheol; (46 pag.)KR2020/4248; (2020); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 29671-92-9, name is Carbamimidic chloride hydrochloride, molecular formula is CH4Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 29671-92-9

Step 2. SO2(CH3)2 (20.4 g, 217 mmol) was heated to melting. A-2 (3.3 g, 29 mmol) was added and the resulting mixture was stirred and heated to 120 C. to dissolve completely. Methyl 5-(2-chloro-4-trifluoromethylphenoxy)-anthranilate (5 g, 14.5 mmol) was added in one part to the reaction mixture. Stirring was continued for 30 minutes. The reaction mixture was treated with water (10 mL) and stirred for 10 minutes. The precipitate, V-17, a white solid, was isolated by filtration and dried in the vacuum oven.LC-MS m/z=356 (M+H)

The chemical industry reduces the impact on the environment during synthesis Carbamimidic chloride hydrochloride. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Janssen R&D Ireland; McGowan, David; Raboisson, Pierre Jean-Marie Bernard; Jonckers, Tim Hugo Maria; Last, Stefaan Julien; Embrechts, Werner; Pieters, Serge Maria Aloysius; US2014/73642; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

13078-79-0, name is 2-(3-Chlorophenyl)ethanamine, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 13078-79-0

To a solution of 13 (40.0mg, 0.09mmol) in 5mL of CH2Cl2 was added the respective amine and the reaction mixture was stirred for 4hat room temperature and N2 atmosphere. Water (20mL) was added to the reaction mixture and the layers were separated. The aqueous layer was extracted with CH2Cl2 (3¡Á40mL), the combined CH2Cl2 layers were washed with water (30mL), dried over anhydrous Na2SO4, filtered and the solvent was removed under vacuum to get the crude product that was purified by preparative TLC (CH2Cl2/MeOH 20:1) to give the urea product.

Statistics shows that 13078-79-0 is playing an increasingly important role. we look forward to future research findings about 2-(3-Chlorophenyl)ethanamine.

Reference:
Article; Figueiredo, Sandra A.C.; Salvador, Jorge A.R.; Cortes, Roldan; Cascante, Marta; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 422 – 437;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

202197-26-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202197-26-0, name is 3-Chloro-4-((3-fluorobenzyl)oxy)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 1; Preparation of GW572016F; STAGE 1; A stirred suspension of 3H-6-iodoquinazolin-4-one (compound A) in toluene (5 vols) was treated with tri-n-butylamine (1.2 eq.) at 20 to 25C, then heated to 900C. Phosphorous oxychloride (1.1 eq) was added, the reaction mixture was then heated to reflux. The reaction mixture was cooled to 500C and toluene (5vols) added. Compound C (1.03 eq.) was added as a solid, the slurry was warmed back to 900C and stirred for 1 hour. The slurry was transferred to a second vessel; the first vessel was rinsed with toluene (2vol) and combined with the reaction mixture. The reaction mixture was cooled to 700C and 1.0 M aqueous sodium hydroxide solution (16 vols) added dropwise over 1 hour to the stirred slurry maintaining the contents temperature between 68-72C. The mixture was stirred at 65-700C for 1 hour and then cooled to 200C over 1 hour. The suspension was stirred at 200C for 2 hours, the product collected by filtration, and washed successively with water (3 x 5 vols) and ethanol (IMS, 2 x 5 vols), then dried in vacuo at 50-600C. Volumes are quoted with respect of the quantity of Compound A used. Percent yield range observed: 90 to 95% as white or yellow crystals.

The synthetic route of 3-Chloro-4-((3-fluorobenzyl)oxy)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SMITHKLINE BEECHAM (CORK) LIMITED; WO2008/67144; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

452-73-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 452-73-3 as follows.

a) Preparation of 5-fluoro-2-methylbenzonitrile Process According to the Invention in MEK By the method of Example 3, 72.5 g of 2-chloro-4-fluorotoluene in 100 ml of MEK gave 46.7 g (68% of theory) of 5-fluoro-2-methylbenzonitrile (boiling point at 30 mbar: 110 C.). After 20 h, the conversion was approximately 80% (GC). 1.2% of coupling products had formed.

According to the analysis of related databases, 2-Chloro-4-fluoro-1-methylbenzene, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer Aktiengesellschaft; US6162942; (2000); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics