A new synthetic route of 1,2-Bis(2-chloroethoxy)ethane

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., 112-26-5

General procedure: A suspension of 4 (1.0g, 3.45mmol) and K2CO3 (0.47g, 3.45 mmol) in acetonitrile (20mL) was heated to 85oC. bis(2-chloroethyl) ether (0.49 g, 3.45 mmol) in acetonitrile (2.0 mL) was added dropwise over 3 h. The mixture was heated at 85oC for 36 h, cooled,and acetonitrile was removed in vacuum. The residue was acidified with dil. HCl (0.45M, 200 mL). The aqueous layer was extracted with chloroform (2¡Á20 mL). The chloroformlayer was dried over Na2SO4 and the solvent evaporated in vacuum to give an oily compound which was purified by column chromatography on silica gel using ethyl acetate: pet ether (2:8 v/v) (7)

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Reference:
Article; Utekar, Druman R.; Samant, Shriniwas D.; Journal of the Korean Chemical Society; vol. 58; 2; (2014); p. 193 – 197;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics