13526-66-4, Adding a certain compound to certain chemical reactions, such as: 13526-66-4, name is 3-Bromo-6-chloroimidazo[1,2-b]pyridazine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13526-66-4.
[00359] EX. 8-29 free base and hydrochloride salt were prepared in 50 g scale according the following procedures. D [00360] To a solution of 3-bromo-6-chloroinnidazo[1 ,2-b]pyridazine (150 g, 0.65 mol) and 3-(trifluoromethyl)phenylboronic(143 g, 0.65 mol) in dioxane/H2O(2.5 L: 4:1 ) was added K2CO3 (180 g, 1 .3 mol) and Pd(PPh3)4 (10 g, 10 mmol). The mixture was stirred at 80 C for 24 h. The solution was concentrated, partitioned with EA/H2O. The aqueous layer was extracted with EA (500ml_) for 3 times. The collected organic layers was dried over Na2SO , concentrated and purified by column chromatograph (PE:EA, 3:1 to 2:1 ) to give 6-chloro-3-(3-(trifluoromethyl)phenyl)imidazo[1 ,2-b]pyridazine (135.15 g, 70.3%) as yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-6-chloroimidazo[1,2-b]pyridazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan; WO2013/13188; (2013); A1;,
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