452-73-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 452-73-3 as follows.
a) Preparation of 5-fluoro-2-methylbenzonitrile Process According to the Invention in MEK By the method of Example 3, 72.5 g of 2-chloro-4-fluorotoluene in 100 ml of MEK gave 46.7 g (68% of theory) of 5-fluoro-2-methylbenzonitrile (boiling point at 30 mbar: 110 C.). After 20 h, the conversion was approximately 80% (GC). 1.2% of coupling products had formed.
According to the analysis of related databases, 2-Chloro-4-fluoro-1-methylbenzene, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bayer Aktiengesellschaft; US6162942; (2000); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics