Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 627-42-9, name is 2-Methoxyethyl chloride, This compound has unique chemical properties. The synthetic route is as follows., 627-42-9
146.5 g (1.2 mol) of 4-hydroxybenzaldehyde are dissolved in DMF, and 2O g (0.12 mol) of potassium iodide, 134.6 g (1.2 mol) of potassium tert-butoxide and 170.2 g (1.8 mol) of 2- chloroethyl methyl ether are added. The reaction mixture is stirred at 800C for 16 h. For work-up, the reaction mixture is concentrated under reduced pressure. The residue is taken up in 1 1 of ethyl acetate and extracted with 0.5 1 of IN aqueous sodium hydroxide solution. The ethyl acetate phase is dried using magnesium sulphate and concentrated under reduced pressure. The residue obtained after concentration is distilled under high vacuum (b.p. = 1000C at 0.45 mbar). This gives 184.2 g (85% of theory) of product.MS (ESIpos): m/z = 181 (M+H)+1H-NMR (300 MHz, CDCl3): delta = 3.5 (s, 3H); 3.8 (tr, 2H); 4.2 (tr, 2H); 7.0 (d, 2H); 7.8 (d, IH); 9.9 (s, IH).
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Reference:
Patent; BAYER HEALTHCARE AG; WO2007/73855; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics