Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-(4-Chlorophenoxy)aniline.
Adding some certain compound to certain chemical reactions, such as: 2770-11-8, name is 2-(4-Chlorophenoxy)aniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2770-11-8. 2770-11-8
Preparation of N-[2-(4-chlorophenoxy)phenyl]-3-acetamido-3-phenylpropanamide STX1858 C23H21ClN2O3, MW: 408.88 EPO To a pre-stirred solution of iV-acetyl-3-phenyl-beta-alanine (104 mg, 0.50 mmol), EDC (265 mg, 1.38 mmol), triethylamine (70 mg, 0.69 mmol) and DMAP (6 mg, 0.046 mmol) in anhydrous DCM (25 ml), was added 2-(4-chlorophenoxy)phenylamine (100 mg, 0.46 mmol). This mixture was then allowed to stir at room temperature for 14 h. The reaction mixture was washed with 2.5M NaOH (20 ml), 2M HCl (20 ml) and the organics were then dried (MgSO4), filtered and concentrated in vacuo. Purification by flash chromatography (eluant; DCM to 9:1 DCM:MeOH) then proceeded to afford the desired product as an off-white solid (58.9 mg, 31%). 1H NMR (270 MHz, CDCl3): delta 2.03 (3H, s, CH3), 2.83-2.99 (2H, m, CH2), 5.30-5.40 (IH, m, CH), 6.73-6.77 (IH, dd, J= 1.5, 8.2 Hz, Ar-H), 6.83-6.86 (2H, m, Ar-H), 6.95-7.03 (IH, td, J= 1.7, 7.9 Hz, Ar-H), 7.05-7.11 (IH, td, J= 1.7, 7.9 Hz, Ar-H), 7.19-7.30 (7H, m, Ar-H), 7.60 (IH, br s, Ar-H), 8.22-8.25 ppm (IH, dd, J – 1.5, 8.0 Hz, Ar-H). LCMS: M+H: 409.44 HPLC: 98.66% (2.268 mins, isocratic 90% acetonitrile, 10% water at 1 rnl/min).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-(4-Chlorophenoxy)aniline.
Reference:
Patent; STERIX LIMITED; WO2007/3934; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics