29882-07-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29882-07-3, name is 4-Chloro-1,1-dimethoxybutane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1. N-(1-Benzylpiperidin-4-yl)-N-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]amine Hydrogen Oxalate 4-(1,2,4-Triazol-4-yl)phenylhydrazine (3 g, 17.12 mmol) and 4-chlorobutyraldehyde dimethyl acetal (2.35 g, 15.41 mmol) were heated at reflux in ethanol/water (5:1, 120 ml) in the presence of concentrated hydrochloric acid (3.77 ml) under nitrogen for 6 hours. The volatiles were evaporated and the residue partitioned between 2M sodium hydroxide (50 ml) and n-butanol. The organic layer was separated and the solvent evaporated. The crude product was purified by column chromatography on silica using dichloromethane/methanol/ammonia (40:8:1) to give 2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine as a brown oil (1.9 g, 49percent).
The synthetic route of 4-Chloro-1,1-dimethoxybutane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme Ltd.; US6140347; (2000); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics